[Skip to Content]
[Skip to Content Landing]
Article
March 1939

CRITERIA FOR THE HISTOLOGIC DIAGNOSIS OF KERATOSIS FOLLICULARIS (DARIER): REPORT OF A CASE WITH VESICULATION

Author Affiliations

BALTIMORE

From the Department of Dermatology of the Johns Hopkins School of Medicine and Hospital.

Arch Derm Syphilol. 1939;39(3):438-455. doi:10.1001/archderm.1939.01480210053006
Abstract

This report of a case of Darier's disease was prompted by the unusual moisture and vesiculation, which were prominent features, and particularly by the confusion of the diagnosis with possible pemphigus vegetans. We wish to stress that the histologic features of Darier's disease are fairly clearcut, that the presence of moisture and crusting has hitherto not been emphasized and that vesiculation may be prominent to a degree which may obscure correct diagnosis. A brief summary of the reports of moist lesions in this rare condition and some comments on its pathogenesis are also in order.

The patient was exhibited at the clinic of the dermatologic section of the Southern Medical Association in November 1936, and the evidence presented for the diagnosis of Darier's disease was generally accepted.

The first case of this disease was reported by White,1 and the pathologic changes were described by J. T. Bowen. There were

×