Chambers and Grand1 have demonstrated that starch is a good chemotactic agent for leukocytes in tissue culture and in animals. It was suggested to me by Dr. E. V. Cowdry that the injection of this substance into the nodules of lupus vulgaris might be of therapeutic value.
PREPARATION OF MATERIAL
Starch U. S. P. (corn starch) was sterilized by baking at 150 C. in an oven, as suggested by Chambers and Grand.1b A 15 per cent suspension was prepared in a sterile rubber-stoppered vial, and only 10 cc. was made up at a time. This makes a heavy suspension which settles on standing. Fresh suspensions were made frequently to avoid contamination. A tuberculin syringe and a 20 or 21 gage needle were used. A smaller needle did not allow free passage of the material. The preparation was injected directly into the nodules at the edge of the
KILE RL. LXXXV.—TREATMENT OF LUPUS VULGARIS BY INJECTIONS OF STARCH U. S. P. (CORN STARCH): REPORT OF A CASE. Arch Derm Syphilol. 1939;39(3):471–473. doi:10.1001/archderm.1939.01480210086008
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