Within the past three years two new tests, the Laughlen and the Ide, have been introduced for the serodiagnosis of syphilis. These tests are called "color tests" and differ from the usual flocculation test in that a dye is added which makes the clumped antigen in a positive reaction more visible. Shortly after the publication of Laughlen's report, prepared antigen was put on the market for use in laboratories and by private physicians. The Ide antigen can likewise be purchased. It is the purpose of this paper to present the results of a comparative study of these tests with the Kline, the Kahn and the Kolmer complement fixation test, in order to inform those performing these tests without controls of what they may expect in the way of specificity and sensitivity. No attempt has been made to improve on the procedures, and directions furnished by the distributors were followed.
FLOOD JM, MAYER V. INADEQUACY OF THE LAUGHLEN AND THE IDE TEST IN THE DIAGNOSIS OF SYPHILIS. Arch Derm Syphilol. 1939;39(3):510–514. doi:10.1001/archderm.1939.01480210125013
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