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March 1939


Arch Derm Syphilol. 1939;39(3):601-612. doi:10.1001/archderm.1939.01480210216029

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Pemphigus Treated with Sulfanilamide; Sulfanilamide Eruption. Presented by Dr. Samuel Feldman.  Mrs. E. S., a housewife aged 57, began to complain of weakness and dizzy spells in the summer of 1937. She became irritable, felt a burning sensation in the chest and complained of pain in the throat, particularly on swallowing. In January 1938 red spots appeared on the back of the tongue, and a bulla was detected on the roof of the mouth. The condition was diagnosed elsewhere as Vincent's angina. The patient had lost about 30 pounds (13.6 Kg.) during the preceding five months, and the condition of the mouth became gradually worse.Early in March 1938 the diagnosis of pemphigus was established. Arsenicals and injections of liver extracts failed to check the progress of the disease. After these injections bullae developed on the buttocks at their sites. From that time on new blebs appeared, and on

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