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A Case for Diagnosis (Arsenical Keratosis?). Presented by Dr. E. William Abramowitz.
M. K. a woman aged 31, presented from the Skin and Cancer Unit of the New York Post-Graduate Medical School and Hospital, has had an eruption on the forearms for fifteen years. On both forearms and the face there are depigmented, hyperpigmented and erythematous irregularly scattered patches with a mottled appearance. On the palms and soles there are numerous punctiform verrucous hyperkeratotic lesions. Examination of the urine showed 0.05 mg. of arsenic per hundred cubic centimeters. A piece of affected skin showed no arsenic.Histologic examination of a specimen taken from the hyperkeratotic lesions showed hyperkeratosis, with nothing to indicate the disease entity. Specimens from the other type of lesions showed an urticarial process. In the first specimen the epidermis was acanthotic and the rete pegs thickened. The granular layer was somewhat increased and the horny layer
Traub EF, Tulipan L. NEW YORK ACADEMY OF MEDICINE, SECTION OF DERMATOLOGY AND SYPHILIS. Arch Derm Syphilol. 1939;39(4):729–749. doi:10.1001/archderm.1939.01480220114016
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