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Article
June 1939

CHRONIC RELAPSING URTICARIA AND ANGIONEUROTIC EDEMA: REPORT OF A CASE WITH ASSOCIATED PANCREATIC INSUFFICIENCY AND RELIEF BY ORAL ADMINISTRATION OF DEINSULINIZED PANCREATIC EXTRACT

Arch Derm Syphilol. 1939;39(6):992-994. doi:10.1001/archderm.1939.01480240040004
Abstract

I am prompted to report a case of the association of cutaneous allergy with pancreatic insufficiency, since a search of medical literature reveals little mention of this unusual syndrome.

REPORT OF CASE  G. S., a white woman aged 51, presented a generalized eruption consisting of whitish and pinkish wheals, accompanied with itching and burning. The onset was on Aug. 20, 1937, and she attributed it to her menopause. The past history revealed nothing significant except a severe attack of mumps at the age of 35. Her recovery was complicated by a peculiar "swelling sensation" across the small of the back, repeated attacks of indigestion and occasional attacks of diarrhea following ingestion of cream or a fatty meal. For the past year she has received hypodermic injections of epinephrine hydrochloride for attacks of angioneurotic edema affecting the lips, tongue and pharyngeal mucous membrane and associated with a generalized urticarial eruption.

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