The object of this paper is to report the results of a treatment for acne and its scars not previously presented in the American literature.
Solidified carbon dioxide was first used in the treatment of acne by Pusey,1 in 1907. As early as 1909 Zeisler2 wrote, "We have in carbon dioxide snow an exceedingly valuable agent with great further possibilities." In 1913 H. Béclère3 employed a mixture of solid carbon dioxide and acetone in silver tubes with pressure. The year before (December 1912), Professor Bordos4 presented before the Academy of Science of Paris a similar apparatus, which he named "cryocautery." This seems to be the origin of the term cryotherapy.
In 1925 Giraudeau,5 at the Hôpital St. Louis, commenced using cryotherapy for acne, with a mixture of solid carbon dioxide, acetone and precipitated sulfur; in 1928 he6 reported this therapeutic method before the therapeutic
KARP FL, NIEMAN HA, LERNER C. CRYOTHERAPY FOR ACNE AND ITS SCARS. Arch Derm Syphilol. 1939;39(6):995–998. doi:10.1001/archderm.1939.01480240043005
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