The purpose of the study reported here was to compare the amount of syphilitic reagin in the serum and in the spinal fluid of patients with neurosyphilis. A number of such studies have already been made, but the results have been inconsistent.1 Whereas, to our best knowledge, all the previous work was done with some variation of the Wassermann technic, one of the flocculation technics, because of their greater simplicity, particularly for quantitative studies, was selected for use in the present investigation. A method which seemed especially suitable for the purpose, because of the clarity of the reactions as well as the relatively small amounts of serum and spinal fluid required, was the Kline test.
The present study differs from previous reported ones also in the greater size of the series studied, namely, a total of 1,245 pairs of serum and spinal fluid. All the specimens tested came from
WIENER AS, DERBY IM. SYPHILITIC REAGIN IN BLOOD AND IN SPINAL FLUIDA COMPARATIVE QUANTITATIVE STUDY. Arch Derm Syphilol. 1939;39(6):999–1005. doi:10.1001/archderm.1939.01480240047006