In the investigations which have been carried out to determine the bactericidal and fungicidal properties of the various antiseptics, iodine stands out as the most valuable one.
Nye1 found that "an aqueous solution of iodine apparently possesses more of the desirable prerequisites for an antiseptic solution than any of the other solutions that were tested." Schamberg and his associates2 stated that "iodine in metallic form appears to be the strongest fungicide."
However, iodine in the form of tincture of iodine or compound solution of iodine U. S. P. has several serious disadvantages: (1) It is caustic; (2) it combines to a great extent with the proteins of the skin and is thus rendered inert, and (3) its volatility is high and therefore its fungicidal action is exerted over a rather short period. Sharlit and Highman,3 who expressed the belief that "iodine is the desirable fungicide," said: "A
LEVER WF. IODOCHOLEATE: A NEW FUNGICIDAL PREPARATION: PRELIMINARY REPORT. Arch Derm Syphilol. 1939;40(1):19–28. doi:10.1001/archderm.1939.01490010022003
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