It has been said that "skin diseases mirror the system," which holds true in various forms of keratoderma associated with disturbances of the endocrine system. Mussio Fournier1 described cases in which keratoses of the palms and soles cleared after treatment with desiccated thyroid. Cervino and his associates2 reported keratoderma of the palms and soles in a girl aged 15 and a woman aged 41 who had basal metabolic rates of —24 and —41 per cent, respectively, and improved greatly under thyroid medication, so that the keratoses became detached in lamellas and ultimately disappeared. Haxthausen3 described keratoses of the palms and soles in 10 women in association with the menopause and accompanied with various signs and symptoms, of which obesity, hypertension and arthritis were the most frequent. The hyperkeratotic process appears in its earliest stages as a discrete sharply defined round or oval lesion of regular form. The
GOLDBERG LC. KERATODERMA CLIMACTERICUM: (HAXTHAUSEN'S DISEASE). Arch Derm Syphilol. 1939;40(1):67–69. doi:10.1001/archderm.1939.01490010070009
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