The treatment of coccidioidal granuloma is of general clinical interest. The endemic character of the infection in certain localities, together with its frequently serious clinicopathologic manifestations and effects, constitutes a challenging demand for effective therapeutic efforts. That such efforts have heretofore proved only partially successful may be readily gleaned from a survey of the available literature dealing with the subject. This will reveal a large variety of therapeutic agents employed in the management of the disease and a correspondingly large variety of contradictory claims of success and failure resulting from their exhibition by the different clinicians.
REVIEW OF THE LITERATURE
Guy and Jacob1 obtained successful therapeutic results in a case of tuberculosis and coccidioidal granuloma by roentgen irradiation of the lesions and intravenous injections of a 1 per cent solution of antimony and potassium tartrate. The injections were administered on alternate days in increasing doses, commencing with 1 cc.