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December 1939


Author Affiliations


From the Department of Dermatology, Johns Hopkins University School of Medicine and the Johns Hopkins Hospital.

Arch Derm Syphilol. 1939;40(6):929-944. doi:10.1001/archderm.1939.01490060067006

Periarteritis nodosa is an inflammatory disease affecting the smaller arteries and arterioles. Almost all the organs and tissues of the body may be involved, giving rise to a variable train of symptoms, depending on where the condition has particularly established itself. The vascular changes may result in a partial or complete cutting off of the blood supply causing impairment of function or localized areas of cell death.

Alkiewicz1 collected from the literature between 1866 and 1933 36 cases in which the skin was affected. In 16 of these there were small macules (kleine Flecken), which were purpuric in 7; in 11 there were nodules; in 15, papules or small nodules; in 7, severe hemorrhages, and in 5, necrosis. In a fairly exhaustive survey of the literature from 1912 to the present we have been able to add 23 cases to those published by Alkiewicz. With over 200 reports in