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Article
January 1940

A SIMPLIFIED COMPLEMENT FIXATION TECHNIC FOR THE DIAGNOSIS AND TREATMENT OF SYPHILIS: ITS SENSITIVITY AND SPECIFICITY

Author Affiliations

PHILADELPHIA

From the Laboratories and the Syphilis Clinic of the Graduate Hospital, University of Pennsylvania.

Arch Derm Syphilol. 1940;41(1):32-37. doi:10.1001/archderm.1940.01490070035003
Abstract

Recently two of us1 described a simplified complement fixation technic for syphilis, the advantages of which include reduction in time and labor, cost and technical errors. Without any loss of specificity, it showed an increased sensitivity over the routine Kolmer modification of the Wassermann test. Preliminary comparisons have also shown it to be more sensitive than the Kahn precipitation test, although less so than the Eagle test. It is now being used at the Graduate Hospital as one of three routine tests on all serums, the other two being the Kahn and the Eagle precipitation test.

A careful record of the results in a series of 1,500 tests (of both syphilitic and nonsyphilitic patients) has furnished us with additional data relative to its significance in the diagnosis of syphilis and the exclusion of syphilis both in patients from the syphilis service and in those admitted to the hospital at

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