Chronic pemphigus vulgaris is a name used to identify a definite disease. Since the principal symptom and primary lesion of this disease is the appearance on the skin and mucous membranes of a number of uncomplicated blisters and since somewhat similar lesions may occur in other diseases, the diagnosis of pemphigus is often a confusing problem in certain cases. There are borderline cases in which dermatitis herpetiformis, erythema multiforme, lupus erythematosus and even certain general infections of the blood stream may be accompanied by numerous bullae and may run a course simulating pemphigus to such a degree that in the absence of other than clinical criteria differentiation is almost a matter of personal opinion or even guesswork. Such cases are relatively rare, but there is a sufficient number of them in the experience of most dermatologists to color the general concept of just what pemphigus is and where it should
MARKHAM FS, ENGMAN MF. LXXXVI.—AN INQUIRY INTO THE CAUSE OF PEMPHIGUS: IS IT A VIRUS DISEASE? Arch Derm Syphilol. 1940;41(1):78–86. doi:10.1001/archderm.1940.01490070081009
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