There is considerable evidence that diseases of the nails, excluding the pyogenic and fungous infections and changes associated with the inflammatory dermatoses, are often produced by endocrine dysfunction, particularly hypothyroidism and hypopituitarism. There is a definite relation between some dermatologic conditions and the endocrine glands. The influence of the hormones on development and function of the skin, hair and nails is well established. In the past five years I have observed more than 30 cases of spontaneous separation of the nails, in a large portion of which there were symptoms indicative of hypothyroidism and a lowered basal metabolic rate. The majority of the patients have improved on medication with thyroid. In a few cases relapse has occurred with the development of new separations of the nails after thyroid medication was discontinued.
Diseases of the nails are many times overlooked, and careful attention to the nails will often be found a
FOX EC. DISEASES OF THE NAILSREPORT OF CASES OF ONYCHOLYSIS. Arch Derm Syphilol. 1940;41(1):98–112. doi:10.1001/archderm.1940.01490070101011
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