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The indolent character and the unusual persistence of the Frei test papule prompted its microscopic study at several stages of its evolution. Three patients with proved lymphogranuloma venereum were given injections of 0.1 cc. of Frei antigen intracutaneously in the arm. Positive reactions developed in all, and no reactions were obtained in other persons who were used as controls. A papule was removed from one patient at the end of twenty-four hours, from another at seventy-two hours and from a third five days after the test was performed. These specimens were prepared according to routine and stained with hematoxylin and eosin.
APPEARANCE AT VARIOUS STAGES
Reaction at Twenty-Four Hour Stage.—
The epidermis showed marked intercellular and intracellular edema. Many of the cells were vacuolated, and in places there was some spongiosis, approaching vesicle formation. In the cutis there was moderate edema, and accumulations of lymphocytes and a few polymorphonuclear leukocytes
Smith LM. HISTOLOGIC STUDY OF THE FREI REACTION PAPULE. Arch Derm Syphilol. 1940;41(1):120–121. doi:10.1001/archderm.1940.01490070123014
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