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This study was undertaken to ascertain whether the addition of chlorobutanol to a suspension of bismuth subsalicylate in oil would produce any untoward effect when the preparation was administered by intramuscular injection. A series totaling 1,440 injections was given to 137 adult patients in the syphilologic division of the clinic under the supervision of Dr. G. D. Astrachan.
Bismuth subsalicylate, 0.13 Gm., suspended in 1 cc. of olive oil with the addition of 3 per cent chlorobutanol was used, and as a control, bismuth subsalicylate, 0.13 Gm., suspended in 1 cc. of olive oil without chlorobutanol or any other addition.
Seven hundred and twenty injections were given of each preparation. Both preparations were given by the same members of the staff in the conventional manner, 2 cc. being injected into the upper outer quadrant of the buttock. Each patient received an intramuscular injection of each preparation alternately once weekly, and
Hoefer HF. EFFECT OF ADDING CHLOROBUTANOL TO BISMUTH SUBSALICYLATE IN OIL INJECTED INTRAMUSCULARLY. Arch Derm Syphilol. 1940;41(2):380–381. doi:10.1001/archderm.1940.01490080189013
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