In spite of the voluminous literature on pruritus ani, the subject remains but little understood. It has not yet been determined whether it is a symptom or a disease entity. Many observers believe that local lesions, such as polyps, hemorrhoids, fissures, fistulas, hypertrophied papillae, infected crypts of Morgagni and infected anal ducts, are important causative factors. Ault1 emphasized the etiologic importance of infection which originates in the anal ducts and in the crypts of Morgagni. On the other hand, Tucker and Hellwig2 stated the belief that pruritus ani is caused by a chemical dermatitis. The latter is said to be due to the passage of feces containing an excess of hydrocarbons, such as skatole.
Local dermatologic conditions, such as neurodermatitis, psoriasis, eczema, seborrheic dermatitis, bacterial and fungous infections and dermatitis medicamentosa, may cause pruritus ani. Systemic diseases, such as diabetes mellitus and hepatic, renal and gastrointestinal diseases and
TURELL R, BUDA AM, MARINO AWM. TREATMENT OF PRURITUS ANI BY TATTOOING WITH MERCURY SULFIDE. Arch Derm Syphilol. 1940;41(3):521–526. doi:10.1001/archderm.1940.01490090073008
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