The concentrations of vitamin C in the blood of 68 apparently healthy persons and in that of 181 patients seen in the dermatologic clinic are reported in this paper. The experimental data on both groups showed wide scattering. No significant correlation was noted in the second group between the concentration of vitamin C in the blood and the development of lesions of the skin. Large amounts of vitamin C1 were given to selected patients, but no therapeutic effects were achieved.
The purpose of this study was confirmation or rejection of the presumption that a deficiency of vitamin C in the body is a contributory etiologic factor in the production of certain diseases of the skin. This presumption has been based on data obtained by several investigators from patients with psoriasis, urticaria, lupus vulgaris, lupus erythematosus, generalized exfoliative dermatitis and eczema. They observed in most instances a low level of
LEVER WF, TALBOTT JH. ROLE OF VITAMIN C IN VARIOUS CUTANEOUS DISEASES. Arch Derm Syphilol. 1940;41(4):657–663. doi:10.1001/archderm.1940.01490100021004
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