Because of the involution of many psoriatic lesions during the summer months, when there is the greatest exposure to sunlight, Krafka1 was led to the hypothesis that large quantities of vitamin D would be beneficial in the treatment of psoriasis. Three patients were treated with halibut liver oil with viosterol or with viosterol in varying amounts up to 20,000 U. S. P. units of vitamin D per day. In 2 cases the condition was of long standing; in the other, of fairly recent origin. In all there was material improvement.
Cedar and Zon2 reported the treatment of 15 patients with irradiated ergosterol. Doses ranged from 300,000 to 400,000 U. S. P. units of vitamin D per day. Of the 15 patients treated, 11 showed complete involution in from six to twelve weeks. Recurrence occurred in 6 patients in six weeks to five months after discontinuance of the treatment.
CLARKE GE. TREATMENT OF PSORIASIS WITH CONCENTRATED VIOSTEROLUNDER THE AUSPICES OF THE CINCINNATI SOCIETY OF DERMATOLOGY AND SYPHILOLOGY. Arch Derm Syphilol. 1940;41(4):664–666. doi:10.1001/archderm.1940.01490100028005
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