Since Broders1 made known his application of natural laws to evolve the principle of grading carcinomas as to their degree of malignancy, this basis for determining the prognosis and the proper treatment for cancer has become more and more essential to the armamentarium of the pathologist, the surgeon and the roentgenologist. Numerous reports2 may be found in the literature concerning its dependability both in determining the prospect for cure and as a guide to the type of treatment which may be most beneficial for a particular condition. The bulk of this work, however, is concerned with the future of the patient rather than with the evolution of the growth itself. Broders1a, b noted a close association of the size of the epitheliomas of the skin and lip and their grade of malignancy, but I have not observed in the literature any attempt to correlate these factors with
WILSON WD. RATE OF ULCERATION OF EPITHELIOMAS OF THE SKIN AND LIP. Arch Derm Syphilol. 1940;41(4):667–677. doi:https://doi.org/10.1001/archderm.1940.01490100031006
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