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April 1940


Arch Derm Syphilol. 1940;41(4):707-710. doi:10.1001/archderm.1940.01490100071012

The erythematous pigmentary fixed eruption first reported by Louis Brocq1 in 1894 was definitely shown to be due to antipyrine. The lesions flared up each time the drug was taken. Since then this type of eruption and others of the urticarial, erythematous and eczematous group, recurring in situ, have been reported following the use of acetophenetidin (phenacetin), acriflavine hydrochloride (trypaflavine), aminopyrine and its compounds, antimony and potassium tartrate, the arsenicals (acetylarsan, arsphenamines, mapharsen and tryparsamide), barbiturates, bismuth salts, cinchophen (atophan), iodides, ipecac, emetine, ipomea (scammony), isacen (diacetyldihydroxyphenylisatin), mercury, phenolphthalein, quinine and the salicylates (acetylsalicylic acid and sodium salicylate). Other agents, such as vaccines, liquors, psychic stress, physical exertion, menstruation and autotoxic substances, have also been implicated.2 Urbach3 reported a fixed eruption from the eating of lentil soup, and Cooke4 observed one which followed the eating of tomatoes. Bowen5 described a similar eruption from a dental