The association of peculiar recurrent cutaneous ulcers with infectious foci in the viscera was first described as a definite clinical syndrome in 1930 by Brunsting, Goeckerman and O'Leary1 and was termed by them pyoderma gangraenosum. The authors pointed out that the symptom-complex had probably been described before under a variety of different names and emphasized the striking parallel relation between the activity of the cutaneous lesions and the major infectious focus. Although somewhat rare, the condition has since been reported regularly and consistently enough to justify its consideration as a separate clinical entity.2 At the same time some of the confusion in the differentiation of pyoderma gangraenosum from other types of cutaneous gangrene has been overcome. In most of the recorded cases the visceral focus has been in the colon, but other viscera may be involved, as in the case of Lane and Stroud2a (biliary and urinary
WEINER AL. PYODERMA GANGRAENOSUM TREATED WITH SULFANILAMIDE: REPORT OF A CASE. Arch Derm Syphilol. 1940;41(4):711–717. doi:10.1001/archderm.1940.01490100075013
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