Multiple tumor nodules in the skin have been reported as occurring in the course of many malignant diseases. Almost every type of epithelioma, sarcoma or lymphoma has been known to involve the skin secondarily, but only a few types, such as melanoma, leukemia, Hodgkin's disease and cancer of the breast and of the stomach have given widespread cutaneous metastases. As such cutaneous involvement is uncommon, we are reporting a case of reticulum cell sarcoma in which the cutaneous manifestations were the outstanding clinical feature.
In considering the differential diagnosis in the case which follows, Recklinghausen's disease, with countless neurofibromatous nodules scattered diffusely over the body, comes first to mind, but the sudden onset and the rapidly fatal course exclude this at once. Generalized lymphadenopathy is strong presumptive evidence of lymphoma as opposed to carcinoma and sarcoma, while a lack of pigmentation is against melanoma. A superficial examination serves to exclude
BINGHAM CT, QUARRIER SS. RETICULUM CELL SARCOMAREPORT OF A CASE WITH PRONOUNCED CUTANEOUS MANIFESTATIONS. Arch Derm Syphilol. 1940;41(4):722–728. doi:10.1001/archderm.1940.01490100086015
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