The observation that strong aqueous solutions of urea (carbamide) possess considerable virucidal power in so far as the agents responsible for rabies and poliomyelitis are concerned1 led me to examine the possibility that they might be useful in the treatment of common warts (verruca vulgaris). These lesions may be transmitted by a sterile filtrate of wart material and are presumably due to a filtrable virus.2 When attempting to make virus vaccines with the aid of urea,1 I observed that urea "solutions" of human warts would not transmit the lesions to the Macacus rhesus monkey, while saline extracts frequently did so. With first hand knowledge of how harmless urea is to normal tissues,3 I had no hesitancy in trying it on warts in human beings.
The results of urea treatment of warts have been good and warrant a more extensive trial of this therapeutic agent. A sterile
MacKay EM. USE OF UREA (CARBAMIDE) IN TREATMENT OF WARTS (VERRUCA VULGARIS). Arch Derm Syphilol. 1940;41(4):736–737. doi:10.1001/archderm.1940.01490100100018
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