Stokes and Sternberg's1 article dealing with the thirteen etiologic factors in the acne complex illustrates how intricate the therapy of this disease may be. Although they expressed the opinion that vitamin deficiency does not play an important etiologic role, they pointed out that the administration of yeast extracts of high potency and the use of liver extract with iron have been well worth while in the treatment of acne but that large doses of vitamin A or D have not been clearly justified.
Doktorsky and Platt2 reported improvement in 100 per cent of 35 patients with acne after a month's treatment with 2,500 to 5,000 U. S. P. units of vitamin D daily. There was 75 to 80 per cent improvement in 90 per cent of the cases, but in 10 per cent relapses occurred within ten days after the treatment was stopped. Maynard3 also expressed optimism
SIMPSON CA, ELLIS FA, KIRBY-SMITH H. VITAMIN D IN THE TREATMENT OF ACNE. Arch Derm Syphilol. 1940;41(5):835–837. doi:10.1001/archderm.1940.01490110021003
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