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May 1940


Author Affiliations


From the Department of Dermatology, University of Illinois Medical School, service of Dr. F. E. Senear.

Arch Derm Syphilol. 1940;41(5):912-918. doi:10.1001/archderm.1940.01490110098014

In recent years there has been an increasingly important role attributed to streptococci acting on the surface of the skin. Because some streptococci have been shown to be peculiarly vulnerable to sulfanilamide in other parts of the body, it seems timely to consider and investigate the excretion of this substance through the skin.

The literature on sulfanilamide has become extraordinarily voluminous in the short time that the product has been available. That part of the literature which has concerned itself with storage has been relatively meager. Pinto1 determined the excretion of sulfanilamide in human milk. He observed that the concentration of the drug in the milk follows that in the blood. The peak of the curve in the milk lags behind that in the blood several hours. He further observed that more than half the sulfanilamide was excreted by the kidneys in the first twenty-four hours. Stewart and Pratt