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May 1940

Argyria. The Pharmacology of Silver

Arch Derm Syphilol. 1940;41(5):995-996. doi:10.1001/archderm.1940.01490110181026

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While there seems to be a sufficiency of large and small dermatologic textbooks at the present time, there are all too few monographs on special subjects in this field. The excellent monograph by Hill and Pillsbury on argyria is therefore most welcome.

A study of the pharmacology of silver in relation to argyria was made possible through a fellowship which was established by the American Silver Producers' Research Project at the University of Pennsylvania. The authors attempted, by an extensive review of the literature, to ascertain the incidence of argyria, the method of its causation and its prevention.

The eight chapters of the monograph include discussions of the historical aspects of argyria, the method of absorption and excretion of silver, its deposition in the tissues and the pharmacophysiologic effects of the administration of silver. Other chapters are devoted to the diagnosis and treatment of argyria, an analysis of recorded cases,

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