There is as yet no agreement on the question as to whether or not the skin of the newborn or young infant has the capacity to form wheals when subjected to stimuli capable of producing wheals in older persons. The decisive answer to this question seems to be of fundamental importance.
For example, the question as to whether the skin of the newborn infant is capable of whealing is of importance in relation to the nature of the wheal reaction produced in many adult skins by certain extracts commonly employed in intracutaneous or scratch testing. Such extracts, in particular those of house dust, cotton linters and human dander, are recognized as producing wheal reactions in the majority of atopic adults and even in many normal adults. But according to most authors, the same extracts, in the usual concentrations, fail to produce wheal reactions in infants under several weeks of age.
SULZBERGER MB, BAER RL. WHEALING CAPACITY OF SKIN OF NEWBORN OR YOUNG INFANTREPORT OF EXPERIMENTS. Arch Derm Syphilol. 1940;41(6):1029–1036. doi:10.1001/archderm.1940.01490120031004
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