In 1927 Higoumenakis presented before the Medical Society of Athens, Greece, a patient with congenital syphilis who showed tumefaction of the inner third of the right clavicle and a roentgenogram of the clavicle of another patient who, besides other stigmas of congenital syphilis, showed enlargement of the sternal extremity of the right clavicle. The author expressed his opinion, based on these observations, that the clavicle sign may be another stigma of congenital syphilis. He was able to verify this assumption by subsequent examination of all patients coming under his observation. The result of the investigation showed that: (1) the clavicle sign has a diagnostic value equal to other definite signs of congenital syphilis; (2) it occurs in greater frequency than the other stigmas of congenital syphilis and consequently is of greater diagnostic value, and (3) it is never encountered in persons with acquired syphilis or in healthy persons.
YANG KL. CLAVICLE SIGN OF LATE CONGENITAL SYPHILIS: REVIEW OF LITERATURE AND REPORT OF SIX CASES. Arch Derm Syphilol. 1940;41(6):1060–1065. doi:https://doi.org/10.1001/archderm.1940.01490120062008
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