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June 1940


Arch Derm Syphilol. 1940;41(6):1141-1151. doi:10.1001/archderm.1940.01490120143019

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Delayed Positive Reaction to Patch Test with Nupercaine Ointment. Presented by Dr. George V. Kulchar.  L. L., a white woman aged 64, is presented. Areas of erythema developed after roentgen ray treatment of a basal cell epithelioma in the left infraorbital region on Sept. 28, 1939. Nupercaine ointment was applied. Two days later acute dermatitis developed at the site of the applications. A patch test was made with nupercaine ointment on the right arm. The reaction was negative at forty-eight hours and remained negative until November 16, forty-five days later, when a strongly positive eczematoid reaction appeared at the site of the patch test and is still present. The dermatitis has disappeared, but a slight roentgen ray reaction still remains.

DISCUSSION  Dr. H. J. Templeton, Oakland: Dr. Alderson, did you not present here some time ago a patient in whom a granulomatous process developed after the use of nupercaine ointment?

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