In a recently published article1 we reported 11 cases of early acute arsenical erythema. In that article we stated that "Not a single recurrence of exactly this type of reaction has ever been reported." Gastro-intestinal disturbances and nitritoid crises seemed to be the most common complications when arsphenamine therapy was resumed.
Since then we have observed 2 cases in which the symptoms characterizing early acute arsenical erythema reappeared one or more times with the resumption of injections of arsenic. Fever, eruptions and adenitis and in 1 case conjunctivitis and punctate keratitis occurred after treatment with arsenicals was resumed. The intensity of these reactions decreased with the number of injections, and administration of the drugs was not permanently stopped because of them.
Further search of the literature shows that Milian2 himself admitted the possibility of a recurrence of the "erythema of the ninth day." He stated that the recurrence
THOMAS EW, CAÑIZARES O. RELAPSING EARLY ACUTE ARSENICAL ERYTHEMA: REPORT OF TWO CASES. Arch Derm Syphilol. 1940;42(1):30–32. doi:10.1001/archderm.1940.01490130034005
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