The introduction of sulfanilamide to the medical profession in 1936 has brought about many changes in therapy in practically every field of medicine. Probably there is no field or specialty in which its value has not been tested clinically as well as experimentally in the laboratory. Nor is there any field in which its value has not been proved as a decided aid to therapy of conditions for which there has been heretofore no valuable remedy.
With the introduction of any new effective drug there is a tendency to extend its use more or less promiscuously. Such spectacular results were obtained with sulfanilamide in many cases of streptococcic infections that it was soon used for all recalcitrant ailments. Its improper use was partly due to the popular belief at the outset that the drug was harmless and did not cause any untoward manifestations. This practice precipitated a large number of
HUGHES RP. THE USE OF SULFANILAMIDE IN DERMATOLOGY. Arch Derm Syphilol. 1940;42(1):33–45. doi:10.1001/archderm.1940.01490130037006
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