After many years of experimental search for a preparation which would produce a significant concentration of bismuth in the central nervous system, Hanzlik, Mehrtens, Gurchot and Johnson1 introduced iodobismitol (sodium iodobismuthite dissolved in ethylene glycol containing 12 per cent sodium iodide) in 1930. The administration of this preparation to animals resulted in greater amounts of bismuth in the nervous system than were obtained with other available compounds. These findings suggested that iodobismitol might be of exceptional value in the treatment of neurosyphilis, and this theoretic effectiveness was supported by the preliminary clinical studies of Mehrtens and Pouppirt.2 No further clinical evaluation of this preparation in the treatment of neurosyphilis has been made, although Johnson and Barnett3 have shown that its use in the routine treatment of early syphilis does not prevent involvement of the nervous system.
Thorough investigation in the laboratory is essential before any drug may
KULCHAR GV, BARNETT CW, CARD JF. IODOBISMITOL WITH SALIGENIN IN THE TREATMENT OF NEUROSYPHILIS. Arch Derm Syphilol. 1940;42(1):46–52. doi:https://doi.org/10.1001/archderm.1940.01490130050007
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