Experimental studies on animals with different sclerosing solutions have been carried out before. Wolf1 studied histologic alterations following injection of solution of mercury bichloride; Meisen2 reported histologic changes following the use of sodium salicylate, and Dörffel,3 changes following the injection of sugar and saline solutions. Similar experimental studies have been made by Regard,4 Schwarz and Ratschow5 and others. As a rule the blood vessels of rabbits' ears have been used, and the veins of dogs and horses have also served.
Comparative studies of different solutions applied to the aural veins and the subcutaneous tissue of rabbits were made by Schubert6 in 1933. He examined and compared the effectiveness of sodium morrhuate solution of 3 to 10 per cent concentration, invert sugar solution of high viscosity and high concentration, hypertonic solution of sodium chloride and alcohol from 70 to 100 per cent. All investigators based
ISAAK L. SCLEROSING SOLUTIONS: A PHOTOGRAPHIC METHOD FOR STUDYING THEIR EFFECTS ON TISSUE. Arch Derm Syphilol. 1940;42(1):86–96. doi:10.1001/archderm.1940.01490130090011
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