Lupus erythematosus is a systemic disease with variable cutaneous manifestations. When the acute or chronic inflammatory reaction involves primarily the upper layers of the skin, it produces a distinctive aspect. On the other hand, when the point of attack of a chronic process is principally centered in the lower half of the cutis and in the subcutis, the resultant picture is entirely unlike that of the superficial variety, for here the clinical phenomenon simulates the sarcoid of Boeck and that of Darier and Roussy and also erythema induratum.
In the interest of better understanding, chronic lupus erythematosus should be subdivided further into three types according to the point of maximum reaction in the skin, namely, the superficial, the median and the deep. The last two types possess infiltrative qualities which produce tumor-like formations. The first type includes both the localized and the disseminate form, which are well known to all
IRGANG S. LUPUS ERYTHEMATOSUS PROFUNDUS: REPORT OF AN EXAMPLE WITH CLINICAL RESEMBLANCE TO DARIER-ROUSSY SARCOID. Arch Derm Syphilol. 1940;42(1):97–108. doi:10.1001/archderm.1940.01490130101012
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