In a study of this type reliance must be placed on serologic tests as a means of gaging the effectiveness of therapy after clinical manifestations have subsided. In assisting in the work it was the purpose of the two laboratories which participated to bring to the study a serologic routine which would be soundly critical, which would be as free as possible from the vagaries attributable to the personal equation, which could be maintained without major technical changes throughout the period of observation of the patients and which could be duplicated for a similar study by any laboratory doing good serologic work.
The complete serologic routine consisted of five tests: three flocculation and two complement fixation tests. The serologic laboratory of the New York City Department of Health, under the direction of Mr. John Koopman, reported results obtained with a quantitative complement fixation technic. The Venereal Disease Research Laboratory of
MAHONEY JF. RÉSUMÉ OF SEROLOGIC OBSERVATIONS. Arch Derm Syphilol. 1940;42(2):262–263. doi:10.1001/archderm.1940.01490140026005
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