[Skip to Navigation]
Article
August 1940

ARSENIC EXCRETION IN THE URINE AND CONCENTRATION IN THE BLOOD

Arch Derm Syphilol. 1940;42(2):270-276. doi:10.1001/archderm.1940.01490140034008
Abstract

EXCRETION OF ARSENIC  In the course of the study of continuous intravenous drip therapy of early syphilis, we had the opportunity to study the excretion of arsenic in the feces and urine of 35 patients during the period of treatment in the hospital. A few years ago the urinary excretion of arsenic was studied in this laboratory after therapy with massive doses of neoarsphenamine in 24 patients.1 The patients had received 2.4 to 5 Gm., with an average of 4 Gm., of neoarsphenamine during the treatment, which lasted for four to six days. The amount of arsenic administered varied between 480 and 1,000 mg., of which 77 to 290 mg. was found to be excreted in the urine. The percentage of elimination varied from 11.6 to 37.2 during the treatment period, usually of five days, with an average of 21.1 per cent.Since a greater fraction of the arsenic

×