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Article
August 1940

NEUROFIBROMATOSIS ASSOCIATED WITH CARCINOMA OF THE BREAST AND PREGNANCY

Arch Derm Syphilol. 1940;42(2):337-340. doi:10.1001/archderm.1940.01490140101018
Abstract

Although neurofibromatosis associated with pregnancy has been reported in a few instances,1 the association of multiple neurofibromas with carcinoma of the breast and pregnancy has not been previously reported.

The influence of pregnancy on the growth of malignant tissues has been observed by a number of clinicians. This phenomenon has also been noted concerning neurofibromas, with increase in size and number of the tumors. The pigmentation becomes more evident, and pain becomes a more predominant symptom. The latter is the result of pressure on the cutaneous nerve filaments by the increase in size and number of the tumors. When pregnancy is terminated, there is a regression in the size and number of the nodules. In the case reported by McNally2 the cutaneous lesions had subsided about 40 per cent eight months after the termination of pregnancy.

When pregnancy again supervenes, the process repeats itself. This is illustrated by

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