It is our purpose not to cite the numerous opinions to be found in the literature regarding the effect of thiosulfate on urinary excretion of arsenic, since this has recently been ably reviewed by Muir, Stenhouse and Becker,1 but to attack this controversial problem from an experimental angle.
Injections of thiosulfate are given for two purposes: (1) to relieve dermatologic symptoms and (2) to aid in diagnosis, the theory being that a course of thiosulfate will lead to exaggerated arsenic excretion in cases in which this element is stored in the tissues. In some clinics it has been the custom to administer thiosulfate on Monday, Wednesday and Friday in 1 Gm. doses and to instruct the patient to collect a twenty-four hour specimen of urine for examination as to arsenic content on the following Saturday. It was this practice which originally interested one of us (M. R. M.) in
MATTICE MR, BAXT H, BYRNE JM. EFFECT OF THIOSULFATE ON ARSENIC EXCRETION. Arch Derm Syphilol. 1940;42(3):399–404. doi:10.1001/archderm.1940.01490150003001
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