One of the tenets held over from the early days of syphilology which is still frequently accepted and taught is the belief that patients with late syphilis of the skin, mucous membrane or bone seldom have neurosyphilis. It is commonly believed that these manifestations of the disease are allergic in origin and influence the immunity reaction so as to protect the neuraxis against involvement by the Spirochaeta pallida. Except so-called "precocious tertiary" lesions of the skin, which are on the borderline between those of early and those of late syphilis, and acute syphilis of the bone, which may occur as a phase of early syphilis, these benign tertiary manifestations as a rule appear after the tenth year of the infection. However, as a result of the discovery that a large number of patients with early syphilis show changes in their spinal fluid due to neuraxis involvement, modern syphilologists agree that
SHAW C. NEUROSYPHILIS AND LATE SYPHILIS OF SKIN, MUCOUS MEMBRANES AND BONES. Arch Derm Syphilol. 1940;42(3):456–460. doi:10.1001/archderm.1940.01490150060010
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