Solid carbon dioxide has been used as a therapeutic agent in dermatology for over a quarter of a century. In 1925 Giraudeau conceived the idea of applying a mixture of carbon dioxide "snow," acetone and sulfur in the form of a slush for the treatment of acne vulgaris and in subsequent communications described the details of the method as well as its rationale.1 In recent years this type of therapy has been introduced in the American literature by Karp, Nieman and Lerner,2 who reported rather striking results. In all the reports thus far issued no detailed attempt has been made to define the circumstances under which the slush method can be used to its best advantage in acne vulgaris, and the reader in perusing these papers is likely either to be skeptical or to gain the impression that this form of treatment can be applied with equal success
DOBES WL, KEIL H. TREATMENT OF ACNE VULGARIS BY CRYOTHERAPY (SLUSH METHOD). Arch Derm Syphilol. 1940;42(4):547–558. doi:10.1001/archderm.1940.01490160007002
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