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October 1940


Author Affiliations


Arch Derm Syphilol. 1940;42(4):570-575. doi:10.1001/archderm.1940.01490160030005

The rarity of xeroderma pigmentosum in Negroes should be of sufficient interest to justify the report of a case in a Negress aged 19. Three cases of xeroderma pigmentosum in a family of African Negroes were described by Loewenthal and Trowell1 in 1938. In their report, of 5 children, aged 8, 7, 3½, 2½ and 1½ years, respectively, only 2 had escaped having the disease. The second and fifth were free of cutaneous manifestations. A striking similarity in the progress of the disease was present in all the cases. When the child was 1½ years old a pruritic pigmented eruption started on the face and soon spread to other parts of the body, resulting in pigmented and depigmented patches. Telangiectasis was not present. Ocular changes appeared soon after the onset, causing total blindness in the 2 older children and visual impairment in the youngest. Tumors of the tongue were