The study of acne is important both because of the frequent occurrence of the disease and because the results of treatment are relatively unsatisfactory. There seems no end to the number and variety of therapeutic agents suggested for use in cases of acne. While many of the suggestions have been well considered and the results of their application well controlled and tested before being reported to the members of the medical profession, their very number and variety suggest that investigative energy might better be devoted to the unsolved fundamental problems of this disease. Among these problems are the relation of acne to the seborrheic state, to infection, to puberty, to the endocrine system and to the metabolism of carbohydrates and fats.
Further work on the association between acne and seborrhea is dependent on more accurate knowledge of the latter condition, particularly the change in the nature and amount of sebum,
LYNCH FW. ACNE VULGARISREVIEW OF HISTOLOGIC CHANGES OBSERVED IN EARLY LESIONS. Arch Derm Syphilol. 1940;42(4):593–606. doi:10.1001/archderm.1940.01490160053008
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