The purpose of this report is to present observations on the therapeutic effect of hypertonic solution of dextrose in patients with serum sickness and with certain types of pruritus. It was observed that a 5 per cent solution of dextrose given by hypodermoclysis relieved the itching of a patient with exfoliative dermatitis of unknown cause. After this experience, it was decided to try the effects of parenteral administration of a hypertonic solution of dextrose, purely on an empiric basis, on patients with other pruritic diseases. We recognize that great care must be exercised in the evaluation of the treatment of subjective symptoms, such as pruritus, but feel that our observations have shown a certain consistency and have been sufficiently controlled to represent reliable material. In some of the cases objective signs, i. e. urticaria, have responded parallel with the subjective manifestations. We have not been able to establish the theoretic
STOUT OM, KOSITCHEK RJ. PARENTERAL USE OF HYPERTONIC DEXTROSE FOR RELIEF OF PRURITUS AND OF SERUM SICKNESS. Arch Derm Syphilol. 1940;42(5):802–807. doi:https://doi.org/10.1001/archderm.1940.01490170050003
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