A genetic relation between epithelioma adenoides cysticum (Brooke), trichoepithelioma and some examples of basal cell cancer has long been suspected. However, the concept that these conditions have a common embryonic origin has received little more than passing comment in the American literature during the past two decades. In short, effort in this field has been directed rather to the establishment of somewhat rigid clinical entities than toward an understanding of pathologic circumstances which might be common to all of them—or, at least, of which they were more or less a considerable part.
Still, certain earlier writers took the broader view of the subject. Indeed, the idea of a possible relation between epithelioma adenoides cysticum and perverted development of hair follicles is as old as the classic description of the disease. Brooke,1 in histologic sections from 2 of his cases, noted that the masses of basal cells in the corium
TRAENKLE HL. EPITHELIOMA ADENOIDES CYSTICUM, TRICHOEPITHELIOMA AND BASAL CELL CANCERRELATION BETWEEN THESE DISEASES, AS SHOWN BY HISTOLOGIC STUDIES OF MULTIPLE BENIGN CYSTIC EPITHELIOMA. Arch Derm Syphilol. 1940;42(5):822–839. doi:10.1001/archderm.1940.01490170070007
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