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December 1940


Arch Derm Syphilol. 1940;42(6):1046-1058. doi:10.1001/archderm.1940.01490180055004

Since Ehrlich's discovery of arsphenamine did not accomplish the desired millennium in the treatment of syphilis, scientific workers have been constantly seeking to improve the known methods of attack on this disease. These endeavors have been directed toward better management of the courses of treatment, modifications in the dosage of drugs, variations in the methods of administration and the addition of new chemical compounds. During the past two years we have conducted a clinical study with a new drug in 84 cases of various types of syphilis. An arsenical compound having the common name of acetylglycarsenobenzene was administered intramuscularly, together with an oil-soluble bismuth compound and insoluble mercury. The patients were a selected group who had not received previous antisyphilitic treatment. In each instance the diagnosis of syphilis was supported by a dark field examination or by a serologic test.

CHEMISTRY  Acetylglycarsenobenzene is chemically 3,4′-diacetylamino-4-hydroxyarsenobenzene 2′-sodium glycolate. The molecular weight