At the present time it is generally accepted that after the intra-muscular administration of a bismuth compound a large portion of the absorbed metal is excreted in the urine and a smaller portion is excreted in the feces, while the remainder is retained in the tissues for varying periods. In general, it appears that the excretion of bismuth in the urine may be considered to be a fair index of actively circulating bismuth, and this is an indication of the rapidity of its absorption from the muscles. Cole and his co-workers1 stated that a preparation which furnishes a more or less continuous daily urinary excretion of 2 to 4 mg. or more of bismuth is potentially a valuable antisyphilitic agent.
In choosing a bismuth preparation the physician should consider the indications for each particular patient. An approved aqueous solution of bismuth administered two or three times weekly produces a
THURMON FM, BENOTTI N. EXCRETION OF BISMUTH IN THE URINE OF PATIENTS TREATED WITH BISMUTH ETHYLCAMPHORATE. Arch Derm Syphilol. 1940;42(6):1073–1082. doi:10.1001/archderm.1940.01490180082006
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