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To the Editor:—
The clinical note by Dr. Leon Goldman on "Ulcerative Reaction from Gentian Violet in the Treatment of Impetigo Contagiosa" (Arch. Dermat. & Syph.42:1122 [Dec.] 1940) reminded me of similar lesions which I have seen in a few patients following the use of a 3 per cent solution of cupric sulfate in the treatment of impetigo. These lesions had thick, adherent crusts and were surrounded by narrow rings of red, edematous skin. Pressure on the center of the crusts caused oozing of a thick yellow pus from under the edges. The crusts were so firmly attached that they could be removed only with scissors and forceps, leaving a necrotic base bathed in a purulent discharge.As I noticed this reaction in only a few of the many lesions of impetigo which I have treated with a solution of cupric sulfate, I assumed that in these cases
Niles HD. ULCERATIVE REACTION TO MEDICATION FOR IMPETIGO. Arch Derm Syphilol. 1941;43(1):160. doi:10.1001/archderm.1941.01490190163014
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