The most generally accepted dermatologic theory is that herpes simplex is a virus disease. As Wise and Sulzberger1 pointed out, "Herpes virus lies latent until an activating or synergistic force decreases local tissue immunity." Some people are immune or carriers of the virus. In one attack, a food or a drug may suffice to act as the synergist, activating the virus to produce the local disease; in another, sunlight; in a third, trauma; in a fourth, a common cold or a sharp rise in temperature; in a fifth and sixth, menses or sexual intercourse.
In a previous communication2 I reported the treatment of scars with blistering doses of ultraviolet rays. In attempting this treatment on a patient with depressed scars following acne, I found that even mild erythema doses of ultraviolet rays caused severe herpes simplex to recur in a certain area on the cheek. This herpes was
FISHER AA. TREATMENT OF HERPES SIMPLEX WITH MOCCASIN SNAKE VENOM. Arch Derm Syphilol. 1941;43(3):444–446. doi:10.1001/archderm.1941.01490210012002
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